Scotland captain Andy Robertson has been ruled out of Thursday’s opening Euro 2020 qualifier in Kazakhstan.
The Liverpool defender had stayed behind in Glasgow when the squad left on Sunday night to have an operation on an abscess in his mouth.
He had hoped to meet his team-mates in Astana, but will instead join them for Scotland’s second match in San Marino on Sunday.
It means Celtic defender Kieran Tierney is likely to deputise at left-back.
Jordan Archer, Barry Bannan and Charlie Mulgrew had already withdrawn from Alex McLeish’s squad, with Liam Kelly and Stuart Findlay called up.
Livingston goalkeeper Kelly and Kilmarnock defender Findlay are both yet to win a cap for their country.
Cardiff City’s Callum Paterson and Ryan Fraser of Bournemouth will also not be involved in Astana due to concerns over the artificial surface.
Dates for FA Cup semi-final fixtures confirmed
Manchester City will open the FA Cup semi-final weekend on April 6 against Brighton & Hove Albion after England’s Football Association announced on Tuesday the schedule for the two fixtures at Wembley Stadium.
City, who are chasing a quadruple of trophies, will take on Brighton in the first semi-final on Saturday at 1730 GMT while Watford face Wolverhampton Wanderers a day later for a 1600 kickoff.
The FA said each club would be allocated approximately 33,000 tickets for their fans and tickets are priced in the range of 30 pounds to 80 pounds.
The final is scheduled for May 18 at Wembley stadium.